Publications

1.     Grassberger C, Trofimov A, Lomax A, Paganetti H. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. International Journal of Radiation Oncology* Biology* Physics. 2011;80(5):1559-66.

·   Featured in MedicalPhysicsWeb in February 2011: (http://medicalphysicsweb.org/cws/article/research/45093)

2.     Grassberger C, Paganetti H. Elevated LET components in clinical proton beams. Physics in medicine and biology. 2011 Sep 30;56(20):6677.

3.     Carabe A, España S, Grassberger C, Paganetti H. Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Physics in medicine and biology. 2013;58(7):2103.

4.     Zeng C, Giantsoudi D, Grassberger C, Goldberg S, Niemierko A, Paganetti H, Efstathiou JA, Trofimov A. Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions. Medical physics. 2013;40(5):051708.

5.     Dowdell S, Grassberger C, Sharp GC, Paganetti H. Interplay effects in proton scanning for lung: a 4D Monte Carlo study assessing the impact of tumor and beam delivery parameters. Physics in medicine and biology. 2013;58(12):4137.

6.     Grassberger C, Dowdell S, Lomax A, Sharp G, Shackleford J, Choi N, Willers H, Paganetti H. Motion interplay as a function of patient parameters and spot size in spot scanning proton therapy for lung cancer. International Journal of Radiation Oncology* Biology* Physics. 2013;86(2):380-6.

·   Featured in MedicalPhysicsWeb in April 2013: (http://medicalphysicsweb.org/cws/article/research/53114)

7.     Giantsoudi D, Grassberger C, Craft D, Niemierko A, Trofimov A, Paganetti H. Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential. International Journal of Radiation Oncology* Biology* Physics. 2013;87(1):216-22.

·   Featured in MedicalPhysicsWeb in August 2013: (http://medicalphysicsweb.org/cws/article/research/54274)

8.     Dowdell S, Grassberger C, Paganetti H. Four-dimensional Monte Carlo simulations demonstrating how the extent of intensity-modulation impacts motion effects in proton therapy lung treatments. Medical physics. 2013;40(12):121713.

9.     Grassberger C, Daartz J, Dowdell S, Ruggieri T, Sharp G, Paganetti H. Quantification of proton dose calculation accuracy in the lung. International Journal of Radiation Oncology* Biology* Physics. 2014;89(2):424-30.

10.  Schuemann J, Dowdell S, Grassberger C, Min CH, Paganetti H. Site-specific range uncertainties caused by dose calculation algorithms for proton therapy. Physics in medicine and biology. 2014;59(15):4007.

11.  Phillips J, Gueorguiev G, Shackleford JA, Grassberger C, Dowdell S, Paganetti H, Sharp GC. Computing proton dose to irregularly moving targets. Physics in medicine and biology. 2014;59(15):4261.

12.  Grassberger C, Lomax A, Paganetti H. Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Physics in medicine and biology. 2014;60(2):633.

13.  Grassberger C, Dowdell S, Sharp G, Paganetti H. Motion mitigation for lung cancer patients treated with active scanning proton therapy. Medical physics. 2015;42(5):2462-9.

·   Featured in MedicalPhysicsWeb in July 2015: (http://medicalphysicsweb.org/cws/article/research/61674)

·   Won 2nd place in the Junior Investigator Competition at the annual meeting of the American Association of Physicists in Medicine

14.  Kooy HM, Grassberger C. Intensity modulated proton therapy. The British journal of radiology. 2015;88(1051):20150195.

15.  Dowdell S, Grassberger C, Sharp G, Paganetti H. Fractionated Lung IMPT Treatments Sensitivity to Setup Uncertainties and Motion Effects Based on Single-Field Homogeneity. Technology in cancer research & treatment. 2015:1533034615595761.

16.  Schuemann J, Giantsoudi D, Grassberger C, Moteabbed M, Min CH, Paganetti H. Assessing the clinical impact of approximations in analytical dose calculations for proton therapy. International Journal of Radiation Oncology* Biology* Physics. 2015;92(5):1157-64.

17.  Varlotto J, DiMaio C, Grassberger C, Tangel M, Mackley H, Pavelic M, Specht C et al. Multi-modality management of craniopharyngioma: a review of various treatments and their outcomes. Neuro Oncology Practice. 2015;10.1093/nop/npv029.

18.  Verburg JM, Grassberger C, Dowdell S, Schuemann J, Seco J, Paganetti H. Automated Monte Carlo simulation of proton therapy treatment plans. Technology in cancer research & treatment. 2016:15(6):NP35-46.

19.  Winterhalter C, Safai S, Grassberger C, Oxley D, Weber DC, Lomax T. Monte Carlo model of a gantry for proton pencil beam scanning. Strahlentherapie und Onkologie. 2016:192(11):837-837.

20.  Manem VS, Grassberger C, Paganetti H. Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors. Cancers. 2017:9(9).

21.  Geng C, Paganetti H, Grassberger C. Prediction of Treatment Response for Combined Chemo-and Radiation Therapy for Non-Small Cell Lung Cancer Patients Using a Bio-Mathematical Model. Scientific reports. 2017:7(1):13542.

·   Featured in MGH Snapshot of Science in October 2017

·   prompted Interview invitation by the Journal of the National Comprehensive Cancer Network (JNCCN) at the annual meeting of the American Society for Radiation Oncology in October 2017: https://jnccn360.org/nsclc/videos/nsclc-therapy-sequencing-criteria/

22.  Botas P, Grassberger C, Sharp G, Paganetti H. Density overwrites of internal tumor volumes in intensity modulated proton therapy plans for mobile lung tumors. Physics in Medicine & Biology. 2018:63(3):035023.

23.  Grassberger C, Hong TS, Hato T, Yeap B, Wo J, Tracy M, Bortfeld T, Wolfgang J, Eyler C, Goyal L, Clark JW, Crane C, Koay E, Cobbold M, DeLaney T, Jain R, Zhu A, Duda DG. Differential Association between Circulating Lymphocyte Populations with Outcome after Radiotherapy in Subtypes of Liver Cancer. . International Journal of Radiation Oncology* Biology* Physics. 2018 Aug 1;101(5):1222-5.

24.  Underwood TS, Grassberger C, Bass R, MacDonald SM, Meyersohn NM, Yeap BY, Jimenez RB, Paganetti H. Asymptomatic late-phase radiographic changes among chest-wall patients are associated with a proton RBE exceeding 1.1. International Journal of Radiation Oncology* Biology* Physics. 2018 Jul 15;101(4):809-19.

25.  Chen Y, Grassberger C, Li J, Hong TS, Paganetti H. Impact of potentially variable RBE in liver proton therapy. Physics in Medicine & Biology. 2018 Sep 21;63(19):195001.

26.  Hong TS, Grassberger C, Yeap BY, Jiang W, Wo JY, Goyal L, Clark JW, Crane CH, Koay EJ, Dima S, Eyler CE. Pretreatment plasma HGF as potential biomarker for susceptibility to radiation-induced liver dysfunction after radiotherapy. NPJ Precision Oncology. 2018 Oct 18;2(1):1-3.

27.  Sung W, Jeong Y, Kim H, Jeong H, Grassberger C, Jung S, Ahn GO, Kim IH, Schuemann J, Lee K, Ye SJ. Computational modeling and clonogenic assay for radioenhancement of gold nanoparticles using 3D live cell images. Radiation research. 2018 Nov;190(5):558-64.

28.  Oesten H, Neubeck CV, Jakob A, Enghardt W, Krause M, McMahon SJ, Grassberger C, Paganetti H, Lühr A. Predicting In Vitro Cancer Cell Survival Based on Measurable Cell Characteristics. Radiation research. 2019 Jun;191(6):532-44.

29.  Li Y, Dykstra M, Best TD, Pursley J, Chopra N, Keane FK, Khandekar MJ, Sharp GC, Paganetti H, Willers H, Fintelmann FJ, Grassberger C. Differential inflammatory response dynamics in normal lung following stereotactic body radiation therapy with protons versus photons. Radiotherapy and Oncology. 2019 Jul 1;136:169-75.

30.  Grassberger C, McClatchy D, Geng C, Kamran SC, Fintelmann F, Maruvka YE, Piotrowska Z, Willers H, Sequist LV, Hata AN, Paganetti H. Patient-specific tumor growth trajectories determine persistent and resistant cancer cell populations during treatment with targeted therapies. Cancer research. 2019 Jul 15;79(14):3776-88.

31.  Sanford, N. N., Pursley, J., Noe, B., Yeap, B. Y., Goyal, L., Clark, J. W., et al. (2019). Protons vs Photons for Unresectable Hepatocellular Carcinoma: Liver Decompensation and Overall Survival Proton Radiotherapy for Hepatocellular Carcinoma. International Journal of Radiation Oncology, Biology, Physics. http://doi.org/10.1016/j.ijrobp.2019.01.076

32.  Sanford NN, Pursley J, Noe B, … , Grassberger C, Hong TS. Protons versus photons for unresectable hepatocellular carcinoma: Liver decompensation and overall survival. International Journal of Radiation Oncology* Biology* Physics. 2019 Sep 1;105(1):64-72.

33.  Hammi A, Paganetti H, Grassberger C. 4D blood flow model for dose calculation to circulating blood and lymphocytes. Physics in Medicine & Biology. 2020 Mar 2;65(5):055008.

·   Featured in IOP PhysicsWorld in Feb 2020:

https://physicsworld.com/a/computational-model-determines-dose-to-blood-during-radiotherapy/

·   Finalist in the Rising Stars competition at ICCR 2019 – International Conference on the Use of Computers in Radiation Therapy

34.  Wang CC, McNamara AL, Shin J, Schuemann J, Grassberger C, Taghian AG, Jimenez RB, MacDonald SM, Paganetti H. End-of-range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer. International Journal of Radiation Oncology* Biology* Physics. 2020 Mar 30.

35.  Pursley J, El Naqa I, Sanford NN, … , Grassberger C. Dosimetric analysis and normal tissue complication probability modeling of Child-Pugh score and Albumin-Bilirubin grade increase after hepatic irradiation. International Journal of Radiation Oncology* Biology* Physics. 2020 Apr 27.

36.  Ho AY, Wright JL, Blitzblau RC, Mutter RW, Duda GD, Norton L, Bardia A, Spring L, Isakoff SJ, Chen JH, Grassberger C, et al. Optimizing Radiotherapy to Boost Systemic Immune Responses in Breast Cancer: A Critical Review for Breast Radiation Oncologists. International Journal of Radiation Oncology* Biology* Physics. 2020 May 14.

37.  Baliga S, Bajaj BV, Kabarriti R, Grassberger C, Patteson B, Yeap B, Fox JL, Garg MK, Yock TI. Prolongation of radiotherapy duration is associated with inferior overall survival in patients with pediatric medulloblastoma and central nervous system primitive neuroectodermal tumors. Pediatric blood & cancer.:e28558.

38.  Mohan R, Liu AY, Brown PD, Mahajan et al. Proton Therapy Reduces the Likelihood of High-Grade Radiation-Induced Lymphopenia in Glioblastoma Patients: Phase II Randomized Study of Protons vs. Photons. Neuro-oncology.:noaa182.

39.  Sung W, Grassberger C, McNamara AL, Basler L, Ehrbar S, Tanadini-Lang S, Hong TS, Paganetti H. A tumor-immune interaction model for hepatocellular carcinoma based on measured lymphocyte counts in patients undergoing radiotherapy. Radiotherapy and Oncology. 2020 Oct 1;151:73-81.

40.  McClatchy DM, Willers H, Hata AN, Piotrowska Z, Sequist LV, Paganetti H, Grassberger C. Modeling Resistance and Recurrence Patterns of Combined Targeted–Chemoradiotherapy Predicts Benefit of Shorter Induction Period. Cancer Research. 2020 Nov 15;80(22):5121-33.

41.  Liu KX, Ioakeim-Ioannidou M, et al. A Multi-institutional Comparative Analysis of Proton and Photon Therapy-Induced Hematologic Toxicity in Patients With Medulloblastoma. International Journal of Radiation Oncology* Biology* Physics. 2021 Mar 1;109(3):726-35.

42.  Grassberger C et al. Circulating Lymphocyte Counts Early During Radiotherapy are Associated with Recurrence in Pediatric Medulloblastoma. International Journal of Radiation Oncology* Biology* Physics. 2021 Feb 5.

43.  Bobić M, Lalonde A, Sharp GC, Grassberger C, Verburg JM, Winey BA, Lomax AJ, Paganetti H. Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy. Physics in Medicine & Biology. 2021 Feb 25;66(5):055023.

44.  De B, Ng SP, Liu AY, Avila S, Tao R, Holliday EB, Brownlee Z, Kaseb A, Lee S, Raghav K, Vauthey JN. Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Radiotherapy. Journal of Hepatocellular Carcinoma. 2021 Mar 3;8:57-69.

45.  Ebrahimi S, Lim G, Liu A,Lin SH, Ellsworth S, Grassberger C, Mohan R, Cao W. Radiation-induced lymphopenia risks of photon versus proton therapy for esophageal cancer patients. Accepted for publication to “International Journal of Particle Therapy” Feb. 1., 2021

46.  Shin J, Xing S, McCullum L, Hammi A, Pursley J, Correa CA, Withrow J, Domal S, Bolch W, Paganetti H, Grassberger C. HEDOS—a computational tool to assess radiation dose to circulating blood cells during external beam radiotherapy based on whole-body blood flow simulations. Physics in Medicine & Biology. 2021 Aug 3;66(16):164001.

·   Awarded the Roberts Prize for the best paper published in 2021

47.  Qian J, Akama-Garren E, Shin J, Gunasti L, Bang A, Pike LR, Grassberger C, Schoenfeld JD. Dosimetric Modeling of Lymphopenia in Metastatic Cancer Patients Receiving Palliative Radiation and PD-1 Immune Checkpoint Inhibitors. Advances in Radiation Oncology. 2021 Dec 24:100880.

48.  Bertolet A, Wehrenberg-Klee E, Bobic M, Grassberger C, Perl J, Paganetti H, Schuemann J. Pre-and post-treatment image-based dosimetry in 90Y-microsphere radioembolization using the TOPAS Monte Carlo toolkit. Physics in Medicine & Biology. 2021 in print

49.  Waldschmidt JM et al. Single-cell profiling reveals metabolic reprogramming as a resistance mechanism in BRAF-mutated multiple myeloma. Clinical Cancer Research. 2021 Dec 1;27(23):6432-44.

50.  Sung W, Hong TS, Poznansky MC, Paganetti H, Grassberger C. Mathematical modeling to simulate the effect of adding radiotherapy to immunotherapy and application to hepatocellular carcinoma. International Journal of Radiation Oncology* Biology* Physics. 2022 Mar;112(4):1055-1062

51.  Chamseddine I, Kim Y, De B, El Naqa I, Duda DG, Wolfgang J, Pursley J, Paganetti H, Wo J, Hong T, Koay EJ, Grassberger C. Predictive Modeling of Survival and Toxicity in Hepatocellular Carcinoma Patients After Radiotherapy. JCO clinical cancer informatics. 2022 Feb;6:e2100169.

52.  Cho Y, Kim Y, Chamseddine I, Lee WH, Kim HR, Lee IJ, Hong MH, Cho BC, Lee CG, Cho S, Kim JS …, Grassberger C. Lymphocyte dynamics during and after chemo-radiation correlate to dose and outcome in Stage III NSCLC patients undergoing maintenance immunotherapy. Radiotherapy and Oncology. 2022 Mar 1;168:1-7.

53.  Ellsworth SG, …, Grassberger C, Lin SH, Mohan R. Lymphocyte depletion rate as a biomarker of radiation dose to circulating lymphocytes during fractionated partial-body radiotherapy. Advances in Radiation Oncology. 2022 Apr 8:100959.

54.  Correa-Alfonso CM, Withrow JD, Domal SJ, Xing S, Shin J, Grassberger C, Paganetti H, Bolch WE. A mesh-based model of liver vasculature: implications for improved radiation dosimetry to liver parenchyma for radiopharmaceuticals. EJNMMI physics. 2022 Dec;9(1):1-27.

55.  Jing W, Xu T, Wu L, Lopez PB, Grassberger C, Ellsworth SG, Mohan R, Hobbs BP, Blumenschein GR, Tu J, Altan M. Severe Radiation-Induced Lymphopenia Attenuates the Benefit of Durvalumab After Concurrent Chemoradiotherapy for NSCLC. JTO clinical and research reports. 2022 Sep 1;3(9):100391.

56.  Im NG, Guillaumet-Adkins A, Wal M, Rogers AJ, Frede J, Havig CC, Yang J, Anand P, Stegmann SK, Waldschmidt JM, Sotudeh N et al. Regulatory programs of B-cell activation and germinal center reaction allow B-ALL escape from CD19 CAR T-cell therapy. Cancer Immunology Research. 2022 Sep 1;10(9):1055-68.

57.  McCullum L, Shin J, Xing S, Beekman C, Schuemann J, Hong T, Duda D, Mohan R, Lin S, Correa-Alfonso CM, … , Grassberger C. Predicting Severity of Radiation Induced Lymphopenia in Individual Proton Therapy Patients for Varying Dose Rate and Fractionation Using Dynamic 4-Dimensional Blood Flow Simulations. International Journal of Radiation Oncology* Biology* Physics. 2023 Feb 4.

58.  Chamseddine I, Kim Y, De B, El Naqa I, Duda DG, Wolfgang JA, Pursley J, Wo JY, Hong TS, Paganetti H, Koay EJ, Grassberger C. Predictive Model of Liver Toxicity to Aid the Personalized Selection of Proton Versus Photon Therapy in Hepatocellular Carcinoma. International Journal of Radiation Oncology* Biology* Physics. 2023 Feb 4.

59.  Correa-Alfonso CM, Withrow J, Domal SJ, President B, Dawson RJ, McCullum L, Beekman C, Grassberger C, Paganetti H, Bolch WE. Intra-brain vascular models within the ICRP mesh-type adult reference phantoms for applications to internal dosimetry. Physics in Medicine and Biology. 2023 Mar 30.

60.  Kim Y, Chamseddine I, Cho Y, Kim JS, Mohan R, Shusharina N, Paganetti H, Lin S, Yoon HI, Cho S, Grassberger C. Neural network based ensemble model to predict radiation induced lymphopenia after concurrent chemo-radiotherapy for non-small cell lung cancer from two institutions. Neoplasia. 2023 May 1;39:100889.

61.  Wheeler G, Grassberger C, Samers J, Dwyer M, Wiltshire K, Daly P, Alvarez B, Campbell BA, Kerr AJ, Kron T, Duane FK. Central Endocrine Complications Among Childhood Cancer Survivors Treated With Radiation Therapy: A PENTEC Comprehensive Review. International Journal of Radiation Oncology* Biology* Physics. 2023 Jun 3.

62.  Ellsworth SG, van Rossum PS, Mohan R, Lin SH, Grassberger C, Hobbs B. Declarations of Independence: How Embedded Multicollinearity Errors Affect Dosimetric and Other Complex Analyses in Radiation Oncology. International Journal of Radiation Oncology* Biology* Physics. 2023 Jul 3.

63.  Wang X, van Rossum PS, Chu Y, Hobbs BP, Grassberger C, Hong TS, Liao Z, Yang J, Zhang X, Netherton T, Mohan R. Severe Lymphopenia During Chemoradiation Therapy for Esophageal Cancer: Comprehensive Analysis of Randomized Phase 2B Trial of Proton Beam Therapy Versus Intensity Modulated Radiation Therapy. International Journal of Radiation Oncology* Biology* Physics. 2023 Aug 29.

64.  Winter SF, Vaios EJ, Shih HA, Grassberger C, Parsons MW, Gardner MM, Ehret F, Kaul D, Boehmerle W, Endres M, Dietrich J. Mitigating Radiotoxicity in the Central Nervous System: Role of Proton Therapy. Current Treatment Options in Oncology. 2023 Sep 20:1-26.

65.  Beekman C, Withrow JD, Alfonso CM, Pathak SP, Dawson RJ, Carrasco-Rojas N, Sforza AR, Colon CG, Bolch WE, Grassberger C, Paganetti H. A stochastic model of blood flow to calculate blood dose during radiotherapy. Physics in Medicine & Biology. 2023 Nov 8;68(22):225007.

66.  Wisdom AJ, Barker CA, Chang JY, Demaria S, Formenti S, Grassberger C, Gregucci F, Hoppe BS, Kirsch DG, Marciscano AE, Mayadev J. The next chapter in immunotherapy and radiation combination therapy–cancer-specific perspectives. International Journal of Radiation Oncology* Biology* Physics. 2024 Jan 5.

67.  Pursley J, Remillard K, Depauw N, Lee G, Grassberger C, Paganetti H, Efstathiou JA, Kamran SC. Radiation Therapy for Stage IIA/B Seminoma: Modeling Secondary Cancer Risk for Protons and VMAT versus 3D Photons. Cancers. 2024 Feb 15;16(4):784.

Book chapters

1.     Grassberger C, Sharp G and Paganetti H. Chapter 10: Proton Therapy. Principles and Practice of Image-guided Radiation Therapy of Lung Cancer. CRC Press 2017

2.     Schuemann J, McNamara A, Grassberger C. Chapter 14: Outcome modeling in Particle therapy. A Guide to Outcome Modeling In Radiotherapy and Oncology: Listening to the Data. Taylor & Francis / CRC Press

3.     Chamseddine I, Kim Y, Grassberger C. Chapter 10: "Data-driven approaches in radiotherapy outcome modeling." Artificial Intelligence in Radiation Therapy. IOP Publishing, 2022.

Published Software/Code

1. HEDOS : A computational framework for HEmatological DOSe calculation in radiotherapy patients https://github.com/mghro/hedos

2. Modeling resistance development during EGFR-targeted tyrosine kinase inhibitors (TKIs) in non-small cell lung cancer patients, model includes the possible effect and clinical benefit of chemo-radiation/TKI combination regimen in locally-advanced disease: https://github.com/bomcclatchy/Modeling-Multimodal-TKI-ChemoRadiation